This term refers to conditions that cause excessive daytime sleepiness, meaning that patients have trouble staying awake during the day 1. Kleinelevin syndrome information page national institute. This was shared by a family living with kls, lucy wanted to raise awareness on rare disease day 2016 about what it is like to live with kleine levin syndrome and i wanted to share her words. Jan 20, 2014 kleine levin syndrome is a recurrent hypersomnia associated with symptoms of hyperphagia, hypersexuality, and cognitive impairment. One of the ways you can help change that is by printing out the kls brochure and sharing it with your community, friends, family, and health care professionals. Symptoms occur as episodes, typically lasting a few days to a few weeks. Kleine levin syndrome kls is the commonest recurrent sleep disorder with a prevalence of 12 per million population. Kleinelevin syndrome is a rare disorder that primarily affects adolescent males approximately 70 percent of those with kleinelevin syndrome are male. Dec 04, 2016 videos sobre tratamentos naturais, doencas, emagrecimento, fitness, vida saudavel e bem estar.
There has been speculation about whether the illnesses ought to be counted as variants of each other an. It is a disease predominantly of teenagers, and boys are four times more likely to be affected than girls. Nature and science of sleep dovepress kls foundation. The sleep disorders kleine levin syndrome kls and narcolepsy have several similarities. The disorder strikes adolescents primarily but can occur in younger children and adults. Because its primary symptom, hypersomnia, is common to a number of disorders, the process by which we diagnose kls is one of exclusion ruling out other conditions that share symptoms. Kls is a rare disorder characterised by recurrent bouts of excessive sleep associated with reduced understanding of the world and altered behaviour. Kleinelevin syndrome was first described by kleine in 1925 and elaborated on by levin in 1936, but it was critchley and hoffman who further defined the syndrome in 1942 and gave it its eponym. Kleine levin syndrome and other inherited sleep disorders exclusion criteria 29583 no structural or inflammatory mslike lesions on brain mri.
Kleinelevin syndrome kls is a rare sleep disorder characterized by persistent episodic hypersomnia and cognitive or mood changes. Kleine levin syndrome is a rare disorder that primarily affects adolescent males approximately 70 percent of those with kleine levin syndrome are male. Spect in the kleinelevin syndrome, a possible diagnostic. Kleinelevin syndrome kls is a rare disorder that causes recurring periods of excessive sleepiness. Patients generally experience recurrent episodes of the condition for more than a decade and may return at a later age. Kleine levin syndrome kls is a rare and complex neurological disorder characterized by recurring periods of excessive amounts of sleep, altered behavior, and a reduced understanding of the world. Kleinelevin syndrome kls is a rare disorder which mainly affects adolescent men. Stanford university center for narcolepsy, palo alto, ca, usa.
Kleinelevin syndrome is rare, affecting an estimated 15 per million individuals. Kleinelevin syndrome is a complex medical disorder that causes recurring periods of excessive drowsiness and sleep up to 20 hours per day. Kleinelevin syndrome kls is a rare and complex neurological disorder characterized by recurring periods of excessive amounts of sleep, altered behavior, and a reduced understanding of the world. The kleinelevin syndrome kls is a rare disorder of periodic hypersomnia and associated symptoms. Kleine levin syndrome is a rare recurrent hypersomnia associated with symptoms of behavioral and cognitive impairment. In some cases, this means up to 20 hours a day are spent sleeping. Diagnosing kls is admittedly a challenge but can be a relief for a family in search of answers. Kleine levin syndrome kls is a rare disorder of unknown etiology. Kleine levin syndrome kls foundation, san jose, california. Kleinelevin syndrome kls is a rare, relapsingremitting disease that affects mostly adolescents.
Mignot1,2 1stanford university center for narcolepsy, 2howard hughes medical institute, palo alto, ca, 3kleinelevin. Pdf the kleine levin syndrome is a differential diagnosis for patients with diurnal excessive sleepiness and a suspicion of narcolepsy. The case is described of a boy with the kleinelevin syndrome in whom prominent behavioural disturbances and the initial absence of a clear cyclical pattern obscured the diagnosis. Kleinelevin syndrome kls is a rare and complex neurological disorder characterized by periods of excessive amounts of. The case is described of a boy with the kleine levin syndrome in whom prominent behavioural disturbances and the initial absence of a clear cyclical pattern obscured the diagnosis. Mignot1,2 1stanford university center for narcolepsy, 2howard hughes medical institute, palo alto, ca, 3kleine levin.
Many patients also experience hyperphagia, hypersexuality and other symptoms. The rarity of the syndrome, in combination with the clinical. Abstract kleine levin syndrome kls is a rare disorder with symptoms that include periodic hypersomnia, cognitive and behavioural disturbances. Click export csv or ris to download the entire page or use the checkboxes to select a subset of records to download. Kleinelevin syndrome kls is a chronic sleep disorder and is one of the central disorders of hypersomnolence cdhs. Spect in the kleinelevin syndrome, a possible diagnostic and. In hypersomnias, idiopathic hypersomnia, kleinelevin syndrome, narcolepsy, news, raising awareness, research, take action. Welcome to kls support uk we are a small charity offering help and support to those affected by kleinelevin syndrome also known as kleine levin syndrome or kls. Pharmacological treatment for kleinelevin syndrome. Kleine levin syndrome kls is a rare disorder that causes recurring periods of excessive sleepiness. Kleinelevin syndrome kls is the commonest recurrent sleep disorder with a prevalence of 12 per million population. Kleinelevin syndrome is rare sleep disorder characterized by episodic hypersomnia, cognitive dysfunction, psychiatric and behavioral disturbances.
Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree. Clear diagnostic criteria are now defined, but effective treatment remains. Pathophysiologic hypotheses include a hypothalamic dysfunction and abnormalities in the central serotonin and dopamine metabolism. Kleine levin syndrome kls foundation home facebook. For language access assistance, contact the ncats public information officer. Mar 12, 2009 kleinelevin syndrome information sheet compiled by. Kleinelevin syndrome is a rare recurrent hypersomnia associated with symptoms of behavioral and cognitive impairment. The relationship between the two syndromes, the praderwilli syndrome and the kleinesyndrome, deserves further study. We are a small charity offering help and support to those affected by kleine levin syndrome also known as kleine levin syndrome or kls. Kls support uk helping families affected by kleinelevin. These singleton recruits will not contribute to the overall singleton monitoring metrics applied to gmcs. Imaging diagnostics refers to brain mri kleinelevin syndrome and other inherited sleep disorders inclusion criteria 29583 recurrent hypersomnia.
Information and translations of kleinelevin syndrome in the most comprehensive dictionary definitions resource on the web. Request pdf kleinelevin syndrome kleinelevin syndrome is a rare recurrent hypersomnia associated with symptoms of behavioral and cognitive impairment. Symptoms may last for days to weeks, include excessive food intake, lack of energy, disorientation, irritability, and sensitivity to noise. Lebensjahrzehnt nach infektionen, schlafentzug, alkoholkonsum oder bagatelltraumen erstmals auftritt.
These serious episodes alternate with periods without any symptoms. Kleine levin syndrome kls is a chronic sleep disorder and is one of the central disorders of hypersomnolence cdhs. It is rare for patients over the age of 30 years to present with their first. Kleine levin hibernation syndrome, familial kleinelevin syndrome, familial hibernation syndrome. Kleine levin syndrome is rare, affecting an estimated 15 per million individuals. Kleinelevin syndrome is a recurrent hypersomnia associated with symptoms of hyperphagia, hypersexuality, and cognitive impairment. Kleinelevin syndrome diagnosis stanford health care. Kleine levin syndrome genetic and rare diseases information. Kleine levin syndrome is a complex medical disorder that causes recurring periods of excessive drowsiness and sleep up to 20 hours per day. Participate in the kls research program blood samples from a new kls patients are tremendously. Pmid 20784073, pmcid pmc2159883, lire en ligne archive pdf modifier. It is characterized by recurring but reversible periods of excessive sleep up to 20 hours per day. Kls is a rare disorder characterised by recurrent bouts of excessive sleep associated with reduced understanding of. Kleinelevin syndrome kleinelevin syndrome treatment.
Definition of kleinelevin syndrome in the dictionary. Jun 21, 20 kleine levin syndrome, kls, or sleeping beauty syndrome is a neurological disorder characterized by recurring periods of excessive amounts of sleeping and. Kleinelevin syndrome kls is a rare sleep disorder characterized by recurrent and unusually long episodes of hypersomnia, associated with behavioralcognitive disturbances, megaphagia and more rarely sexual disinhibition. In dsmiv 9 the condition is covered by dyssomnianos while astheicdi0 10 classifies this condition in the chapter vi in diseases ofthe nervous system. Pdf spect in the kleinealevin syndrome, a possible.
Recurrent episodes of excessive daytime sleepiness lasting for 2 days4 weeks episodes recur at least once per year alertness, cognitive function and behavior are normal between episodes hypersomnia and at least 1. Results for kleine levin syndrome 1 4 of 4 sorted by relevance date. Oliveira mm, conti c, saconato h, fernandes do prado g. Kleine levin syndrome archives hypersomnia foundation. Forgotten diseases research foundation kleinelevin. Act today and let your voice be heard very recently, the hypersomnia foundation became aware of an opportunity to help shape the future of sleep research. Awareness of kleine levin syndrome kls is very low. First and foremost, both typically first impact young people in the form of hypersomnia, that is, overwhelming sleepiness with sleep attacks. It is characterized by episodes lasting from 1 to several weeks, and comprises neurological hypersomnia, confusion, slowness, amnesia and neuropsychiatric symptoms derealization and apathy.
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